Neuroprotective and Anti-Microglial Activation Effects of Tocotrienols in Brains of Lipopolysaccharide-Induced Inflammatory Model Mice

Inflammation is the cause and/or result of many diseases in peripheral tissues and central nervous system. Recent findings suggested that inflammation tissue induces an inflammatory response brain activates glial cells, which, turn, induce neuronal cell dysfunction. Therefore, anti-inflammatory compounds are important for suppression chronic prevention disease. The present study revealed microglial activation hippocampus two days after administration lipopolysaccharide (LPS). Furthermore, expression synaptic vesicle membrane protein, synaptophysin, CA3 stratum lucidum was down-regulated 7 LPS injection. tocotrienols, a type vitamin E, significantly attenuated these changes hippocampus. Collectively, results demonstrated spread responses to brain, which dysfunction were induced, while tocotrienols exerted effects protected neurons from damage.